PROJECTS

PROJECT:

Novel Clinical Brain Tumor Treatments and Diagnostics

Fluorescence-Guided Surgery Using 5-Aminolevulinic Acid/Protoporphyrin IX in Brain Metastases.

Price A, Bernstock JD, Truong N, Wu K, Lee JYK, Tucker IJ, Gessler F, DeSena S, Friedman G, Valdes PA. Neurosurg Pract. 2024 Nov 19;5(4):e00121. doi: 10.1227/neuprac.0000000000000121. eCollection 2024 Dec. PMID: 39959547 

PROJECT:

Hyperspectral Technologies

Editorial: Advancements in intraoperative optical technologies for neurosurgery guidance.

Montcel B, Caredda C, Valdés PA. Front Neurosci. 2024 Dec 4;18:1527174. doi: 10.3389/fnins.2024.1527174. eCollection 2024. PMID: 39697777 

PROJECT:

Hyperspectral Technologies

Hyperspectral imaging in neurosurgery: a review of systems, computational methods, and clinical applications.

Kotwal A, Saragadam V, Bernstock JD, Sandoval A, Veeraraghavan A, Valdés PA. J Biomed Opt. 2025 Feb;30(2):023512. doi: 10.1117/1.JBO.30.2.023512. Epub 2024 Nov 13. PMID: 39544341 

PROJECT:

Novel Clinical Brain Tumor Treatments and Diagnostics

Next-generation CAR T cell therapies for glioblastoma.

Bernstock JD, Gerstl JVE, Valdés PA, Friedman GK, Chiocca E.

Sci Transl Med. 2024 Aug 28;16(762):eadp2660. doi: 10.1126/scitranslmed.adp2660. Epub 2024 Aug 28. PMID: 39196960 Review.

PROJECT:

Super-resolution Imaging Technologies

Inefficient tissue immune response against MPXV in an immunocompromised mpox patient.

Matschke J, Hartmann K, Pfefferle S, Wang Y, Valdes PA, Thies E, Schweizer M, Lütgehetmann M, Schmiedel S, Bernreuther C, Boyden ES, Glatzel M, Krasemann S.

J Med Virol. 2024 Jul;96(7):e29811. doi: 10.1002/jmv.29811. PMID: 39011825

PROJECT:

Novel Clinical Brain Tumor Treatments and Diagnostics

Recurrent Glioblastoma-Molecular Underpinnings and Evolving Treatment Paradigms.

Chang C, Chavarro VS, Gerstl JVE, Blitz SE, Spanehl L, Dubinski D, Valdes PA, Tran LN, Gupta S, Esposito L, Mazzetti D, Gessler FA, Arnaout O, Smith TR, Friedman GK, Peruzzi P, Bernstock JD.

Int J Mol Sci. 2024 Jun 19;25(12):6733. doi: 10.3390/ijms25126733.

PMID: 38928445 Free PMC article. Review.

PROJECT:

Novel Clinical Brain Tumor Treatments and Diagnostics

The Case for Neurosurgical Intervention in Cancer Neuroscience.

Bernstock JD, Gerstl JVE, Chen JA, Johnston BR, Nonnenbroich LF, Spanehl L, Gessler FA, Valdes PA, Lu Y, Srinivasan SS, Smith TR, Peruzzi P, Rolston JD, Stone S, Chiocca EA.

Neurosurgery. 2024 Jun 21. doi: 10.1227/neu.0000000000003039. Online ahead of print. PMID: 38904388

PROJECT:

Novel Clinical Brain Tumor Treatments and Diagnostics

Combination Immunotherapy with Vaccine and Oncolytic HSV Virotherapy Is Time Dependent.

Totsch SK, Ishizuka AS, Kang KD, Gary SE, Rocco A, Fan AE, Zhou L, Valdes PA, Lee S, Li J, Peruzzotti-Jametti L, Blitz S, Garliss CM, Johnston JM, Markert JM, Lynn GM, Bernstock JD, Friedman GK.

Mol Cancer Ther. 2024 Sep 4;23(9):1273-1281. doi: 10.1158/1535-7163.MCT-23-0873. PMID: 38710101

PROJECT:

Program Development

The first neurosurgical service in Texas: neurosurgery at the University of Texas Medical Branch (1937-2023).

Valdés PA, Husain A, Alonzo A, Price A, Nia AM, Maynard K, Costa M, Karas PJ, Lall RR, Briner RP, Kan P.

J Neurosurg. 2024 Apr 5;141(4):1124-1132. doi: 10.3171/2024.1.JNS232418. Print 2024 Oct 1.PMID: 38579354



PROJECT:

Super-resolution Imaging Technologies

Improved immunostaining of nanostructures and cells in human brain specimens through expansion-mediated protein decrowding.

Valdes PA, Yu CJ, Aronson J, Ghosh D, Zhao Y, An B, Bernstock JD, Bhere D, Felicella MM, Viapiano MS, Shah K, Chiocca EA, Boyden ES.

Sci Transl Med. 2024 Jan 31;16(732):eabo0049. doi: 10.1126/scitranslmed.abo0049. Epub 2024 Jan 31.

PMID: 38295184

**Cover Issue

PROJECT:

Hyperspectral Imaging Technologies

5-ALA induced PpIX fluorescence spectroscopy in neurosurgery: a review.

Gautheron A, Bernstock JD, Picart T, Guyotat J, Valdés PA, Montcel B.

Front Neurosci. 2024 Jan 29;18:1310282. doi: 10.3389/fnins.2024.1310282. eCollection 2024. PMID: 38348134 Free PMC article. Review.

PROJECT:

Mapping of Brain Networks

Development of an educational method to rethink and learn oncological brain surgery in an "a la carte" connectome-based perspective. 

Valdes PA, Ng S, Bernstock JD, Duffau H. 

Acta Neurochir (Wien). 2023 May 18. doi: 10.1007/s00701-023-05626-2. Online ahead of print. PMID: 37199758

PROJECT:

Mapping of Brain Networks

Intraoperative functional remapping unveils evolving patterns of cortical plasticity.

Ng S, Valdes PA, Moritz-Gasser S, Lemaitre AL, Duffau H, Herbet G.

Brain. 2023 Jul 3;146(7):3088-3100. doi: 10.1093/brain/awad116.

PMID: 37029961

PROJECT:

Hyperspectral Imaging Technologies

Challenges in, and recommendations for, hyperspectral imaging in ex vivo malignant glioma biopsy measurements.

Walke A, Black D, Valdes PA, Stummer W, König S, Suero-Molina E.

Sci Rep. 2023 Mar 7;13(1):3829. doi: 10.1038/s41598-023-30680-2. PMID: 36882505 

PROJECT:

Novel Clinical Brain Tumor Treatments and Diagnostics

Cerebellar High-Grade Glioma: A Translationally Oriented Review of the Literature.

Raghu ALB, Chen JA, Valdes PA, Essayed W, Claus E, Arnaout O, Smith TR, Chiocca EA, Peruzzi PP, Bernstock JD.

Cancers (Basel). 2022 Dec 28;15(1):174. doi: 10.3390/cancers15010174.PMID: 36612169 

Immunotherapy approaches for the treatment of diffuse midline gliomas.

Bernstock JD, Hoffman SE, Kappel AD, Valdes PA, Essayed W, Klinger NV, Kang KD, Totsch SK, Olsen HE, Schlappi CW, Filipski K, Gessler FA, Baird L, Filbin MG, Hashizume R, Becher OJ, Friedman GK.

Oncoimmunology. 2022 Sep 26;11(1):2124058. doi: 10.1080/2162402X.2022.2124058. eCollection 2022. PMID: 36185807 

Standard clinical approaches and emerging modalities for glioblastoma imaging.

Bernstock JD, Gary SE, Klinger N, Valdes PA, Ibn Essayed W, Olsen HE, Chagoya G, Elsayed G, Yamashita D, Schuss P, Gessler FA, Paolo Peruzzi P, Bag AK, Friedman GK.

Neurooncol Adv. 2022 May 26;4(1):vdac080. doi: 10.1093/noajnl/vdac080. eCollection 2022 Jan-Dec. PMID: 35821676 

Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells.

Bhere D, Choi SH, van de Donk P, Hope D, Gortzak K, Kunnummal A, Khalsa J, Revai Lechtich E, Reinshagen C, Leon V, Nissar N, Bi WL, Feng C, Li H, Zhang YS, Liang SH, Vasdev N, Essayed W, Quevedo PV, Golby A, Banouni N, Palagina A, Abdi R, Fury B, Smirnakis S, Lowe A, Reeve B, Hiller A, Chiocca EA, Prestwich G, Wakimoto H, Bauer G, Shah K.

Nat Commun. 2022 May 19;13(1):2810. doi: 10.1038/s41467-022-30558-3.

PMID: 35589724 

Therapeutic cancer vaccines for pediatric malignancies: advances, challenges, and emerging technologies.

Olsen HE, Lynn GM, Valdes PA, Cerecedo Lopez CD, Ishizuka AS, Arnaout O, Bi WL, Peruzzi PP, Chiocca EA, Friedman GK, Bernstock JD.

Neurooncol Adv. 2021 Feb 11;3(1):vdab027. doi: 10.1093/noajnl/vdab027. eCollection 2021 Jan-Dec. PMID: 33860227